"We have appealed [against the red card] and our appeal was turned down," Everton manager Moyes told a media conference on Friday.

"We haven't been given any reason why it was turned down, but we did appeal it - immediately."

Gueye has started every Premier League game for Everton this season and is due to join up with Senegal for the Africa Cup of Nations in December.

Moyes is also without German midfielder Merlin Rohl, who recently had hernia surgery, while a minor hamstring issue sidelines captain Seamus Coleman, who was substituted in the first half at Old Trafford amid a season beset by injury concerns.

Everton's Premier League campaign continues at Hill Dickinson Stadium on Saturday, when they host Newcastle (17:30 GMT).